According to rescue workers who arrived at the scene, some of the injured had to be rescued from the crushed minibus, and were taken to hospitals by ambulance and by military helicopter.
This is the second lethal accident on Route 90 in just five days.
On Tuesday, an entire family from the Samaria community of Psagot were killed in a collision on the same road near Ein Bokek: Yariv Atar, 45, his wife Shoshi, 47, and their six children.