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September 15, 2016 4:26 am

Strides in ALS Treatment Made at Israel’s Ben-Gurion University

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Ben Gurion University campus. Photo: Yehudit Garinkol.

Ben-Gurion University campus. Photo: Yehudit Garinkol.

JNS.org — A new study published by researchers from Ben-Gurion University (BGU) in the Negev explores a molecular mechanism that could help develop new treatments for ALS, also known as Lou Gehrig’s disease.

Published online in Proceedings of the National Academy of Sciences of the United States of America (PNAS), the study done on mice found that a gene regulating cell inflammation and immunity acts as a chaperone to the misfolded protein that causes the death of motor neurons found in 20 percent of genetic ALS cases. When the researchers eliminated this gene, they found the accumulation of the protein increased and the disease accelerated.

“This study provides insight into the potential therapeutic role” of the studied gene, said Dr. Adrian Israelson, head of the cellular and molecular neurodegeneration lab in the BGU Department of Physiology and Cell Biology.

“Correct protein folding is critically important, which is why we are focusing on the diverse set of complex cellular mechanisms, including molecular chaperones, that promote efficient folding and prevent toxicity,” Israelson said.

ALS is a fatal neurodegenerative disease that destroys motor neurons which control voluntary movement of the muscles.

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  • Jay Lavine

    Okay, now it’s been corrected.

    However, there is another article about ALS that was published on this web site over four years ago: “Orthodox Rabbi May be First ALS Patient Cured by Israeli Drug.” It concerned haredi Rabbi Refoel Shmulevitz. The article states that he may have been cured of his disease. He was not, and he died near the beginning of this year, reportedly of the diseases from which he was said to suffer, namely, ALS and myasthenia gravis.

    It’s wrong to give people false hope, and it’s wrong to provide a forum for people pushing bogus “cures” in the comments section. This web site has been continuing to list that article in the “Most Read in News” section on the “News” web page. The article should be deleted.

  • Jay Lavine

    Another misleading article. When it says “the disease accelerated,” it fails to state that this was an experiment done on mice, not a study done on people with ALS.